000			01638 a2200205 4500
999			_c30779 _d30779
001			nam a22 7a 4500
020			_a9781482217889
082			_a572.8629 WA NE
100			_aWang, Xinkun _9755
245			_aNext-generation sequencing data analysis / _cXinkun Wang
260			_aBoca Raton : _bCRC Press Taylor & Francis Group, _cc2016.
300			_axv, 246 p. : _bill. ; _c24 cm.
505			_aIncludes bibliographical references and index.
520			_aThe development of genome and transcriptome sequencing technologies has led to a paradigm shift in life science research and disease diagnosis and prevention. Scientists are now able to see how human diseases and phenotypic changes are connected to DNA mutation, polymorphism, genome structure, and epigenomic abnormality. Next-Generation Sequencing Data Analysis shows how next-generation sequencing (NGS) technologies are applied to transform nearly all aspects of biological research. The book walks readers through the multiple stages of NGS data generation and analysis in an easy-to-follow fashion. It covers every step in each stage, from the planning stage of experimental design, sample processing, sequencing strategy formulation, the early stage of base calling, reads quality check and data preprocessing to the intermediate stage of mapping reads to a reference genome and normalization to more advanced stages specific to each application.
650			_aGenomics _92462
650			_aSequence Analysis, DNA _vmethods _92463
650			_aGenomes _92464
856			_uhttps://uowd.box.com/s/h9s7x66x87tbcetegd7z254t9d87r5l4 _zLocation Map
942			_cREGULAR