Next-generation sequencing data analysis /
By: Wang, Xinkun
Publisher: Boca Raton : CRC Press Taylor & Francis Group, c2016.Description: xv, 246 p. : ill. ; 24 cm.ISBN: 9781482217889Subject(s): Genomics | Sequence Analysis, DNA -- methods | GenomesDDC classification: 572.8629 WA NE Online resources: Location MapItem type | Home library | Call number | Status | Date due | Barcode | Item holds |
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REGULAR | University of Wollongong in Dubai Main Collection | 572.8629 WA NE (Browse shelf) | Available | T0012167 |
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571.74 MA CE Cellular signal processing : | 571.89 CL ON Cloning / | 572.092 AB WI Wings of fire : | 572.8629 WA NE Next-generation sequencing data analysis / | 574 WA BI Biology, the science of life. | 576 GO IN Individual development and evolution : | 576.801 CO EQ The equations of life : |
Includes bibliographical references and index.
The development of genome and transcriptome sequencing technologies has led to a paradigm shift in life science research and disease diagnosis and prevention. Scientists are now able to see how human diseases and phenotypic changes are connected to DNA mutation, polymorphism, genome structure, and epigenomic abnormality. Next-Generation Sequencing Data Analysis shows how next-generation sequencing (NGS) technologies are applied to transform nearly all aspects of biological research.
The book walks readers through the multiple stages of NGS data generation and analysis in an easy-to-follow fashion. It covers every step in each stage, from the planning stage of experimental design, sample processing, sequencing strategy formulation, the early stage of base calling, reads quality check and data preprocessing to the intermediate stage of mapping reads to a reference genome and normalization to more advanced stages specific to each application.